Spectrophotometric Method for the Determination of Tranexamic Acid in Bulk and Dosage Forms
نویسندگان
چکیده
A simple spectrophotometric method for the determination of tranexamic acid in pure form and pharmaceutical preparations was developed. The method is based on coupling tranexamic acid with 2,6-dichloroquinone-4-chlorimide (DCQ) in dimethyl sulfoxide (DMSO) to produce a colored product which absorbs maximally at wavelength ( ) 670nm. The molar ratio of tranexamic acid: DCQ is 2:1. Beer’s law is max obeyed in the concentration range 50-250 μg/ml of tranexamic acid with molar absorbtivity ( ) of 0.52×10 Lmol 3 1 cm . Different experimental parameters affecting the development and stability of the color were studied and 1 optimized. The proposed method was validated against an adopted B.P formal titration method. The mean percentage recovery for the assay of commercial capsules was found to be 101.13±1.04.
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